Substrate: Cyclin dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1))
Seq-ID: P46414 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cyclin-dependent protein kinase inhibitor activity cytosol,
nucleus		 negative regulation of cyclin-dependent protein kinase activity,
positive regulation of cell proliferation,
negative regulation of apoptosis,
cell cycle arrest,
cellular response to antibiotic,
cellular response to organic cyclic substance,
sensory perception of sound,
potassium ion transport,
positive regulation of microtubule polymerization,
negative regulation of cellular component movement,
negative regulation of epithelial cell proliferation involved in prostate gland development,
inner ear development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 10  MSNVRVSNGSPSLERMDARQ DYRK1B 15010468
LTP
1.00
 - -
0.74
 - medium
S 178 NRTEENVSDGSPNAGTVEQTP - 12856081
LTP
0.26
 - -
0.93
 - medium
T 187 GSPNAGTVEQTPKKPGLRRQT - 12856081
LTP
0.97
 - -
0.93
 - medium

Substrate: Cyclin dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1))
Seq-ID: P46527 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-17680   AKT1_HUMAN
MINT-17889   1433T_HUMAN
MINT-63858   GDIR1_HUMAN
MINT-1779946   MCM7_HUMAN
MINT-3379700   CDK2_HUMAN
MINT-3379718   CDK4_HUMAN
MINT-7219650   GRB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cyclin-dependent protein kinase inhibitor activity,
transforming growth factor beta receptor, cytoplasmic mediator activity,
protein binding		 cytosol,
nucleus		 negative regulation of kinase activity,
regulation of cyclin-dependent protein kinase activity,
negative regulation of cell proliferation,
negative regulation of cell growth,
cell cycle arrest,
G1/S transition of mitotic cell cycle,
autophagic cell death,
cellular response to lithium ion,
induction of apoptosis,
negative regulation of gene-specific transcription
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 10  MSNVRVSNGSPSLERMDARQ - 15302935
HTP
0.28
 - -
0.76
 --
S 10  MSNVRVSNGSPSLERMDARQ KIS 12093740
LTP
0.28
 - -
0.76
 --
S 10  MSNVRVSNGSPSLERMDARQ - 12042314
LTP
0.28
 - -
0.76
 --
S 10  MSNVRVSNGSPSLERMDARQ - 15735731
LTP
0.28
 - -
0.76
 --
S 10  MSNVRVSNGSPSLERMDARQ - 14504289
LTP
0.28
 - -
0.76
 --
S 10  MSNVRVSNGSPSLERMDARQ - 12482975
LTP
0.28
 - -
0.76
 --
S 10  MSNVRVSNGSPSLERMDARQ PKB_group 16780593
LTP
0.28
 - -
0.76
 --
Y 74 FQNHKPLEGKYEWQEVEKGSL SRC 17254967
LTP
1.00
 - CDI
0.62
 --
Y 74 FQNHKPLEGKYEWQEVEKGSL - 18454177
LTP
1.00
 - CDI
0.62
 --
S 83 KYEWQEVEKGSLPEFYYRPPR - 15034923
LTP
0.18
 MOD_CK2_1
 - -
0.59
 1JSU 65.57%
Y 88 EVEKGSLPEFYYRPPRPPKGA - 16195327
LTP
1.00
 - -
0.68
 1JSU 70.31%
Y 88 EVEKGSLPEFYYRPPRPPKGA - 17254966
LTP
1.00
 - -
0.68
 1JSU 70.31%
Y 88 EVEKGSLPEFYYRPPRPPKGA SRC 17254967
LTP
1.00
 - -
0.68
 1JSU 70.31%
Y 89 VEKGSLPEFYYRPPRPPKGAC - 16195327
LTP
0.22
 - -
0.67
 1JSU 36.68%
Y 89 VEKGSLPEFYYRPPRPPKGAC SRC 17254967
LTP
0.22
 - -
0.67
 1JSU 36.68%
S 140 LVDPKTDPSDSQTGLAEQCAG - 17525332
HTP
0.85
 - -
0.82
 --
T 157 QCAGIRKRPATDDSSTQNKRA PKB_group 12244301
LTP
0.94
 MOD_PKB_1
 - -
0.85
 --
T 157 QCAGIRKRPATDDSSTQNKRA PKB_group 12244302
LTP
0.94
 MOD_PKB_1
 - -
0.85
 --
T 157 QCAGIRKRPATDDSSTQNKRA PKB_group 12244303
LTP
0.94
 MOD_PKB_1
 - -
0.85
 --
S 178 NRTEENVSDGSPNAGSVEQTP MAPK1 10831586
LTP
0.15
 MOD_ProDKin_1
 - -
0.94
 --
S 178 NRTEENVSDGSPNAGSVEQTP - 22067460
HTP
0.15
 MOD_ProDKin_1
 - -
0.94
 --
T 187 GSPNAGSVEQTPKKPGLRRRQ - 10831586
LTP
1.00
 MOD_CDK_SPxK_1
 - -
0.94
 --
T 187 GSPNAGSVEQTPKKPGLRRRQ CDK2 12700233
LTP
1.00
 MOD_CDK_SPxK_1
 - -
0.94
 --
T 187 GSPNAGSVEQTPKKPGLRRRQ - 12042314
LTP
1.00
 MOD_CDK_SPxK_1
 - -
0.94
 --
T 187 GSPNAGSVEQTPKKPGLRRRQ - 15735731
LTP
1.00
 MOD_CDK_SPxK_1
 - -
0.94
 --
T 198 PKKPGLRRRQT           - 12042314
LTP
0.00
 YWHAQ 14-3-3 -
0.54
 --
T 198 PKKPGLRRRQT           RSK_group 14504289
LTP
0.00
 YWHAQ 14-3-3 -
0.54
 --
T 198 PKKPGLRRRQT           RSK-2 14504289
LTP
0.00
 YWHAQ 14-3-3 -
0.54
 --

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